Image-based modelling of organogenesis
نویسندگان
چکیده
منابع مشابه
Image-based modelling of organogenesis
One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties and functionalities arise from the molecular regulatory networks-and how can they change as a result of mutations? Morphogenesis provides an excellent model system to study how simple molecular networks robustly control complex processe...
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Mathematical Modelling has a long history in developmental biology. Advances in experimental techniques and computational algorithms now permit the development of increasingly more realistic models of organogenesis. In particular, 3D geometries of developing organs have recently become available. In this paper, we show how to use image-based data for simulations of organogenesis in COMSOL Multi...
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Advances in imaging technology now provide us with detailed 3D data on gene expression patterns in developing embryos. This information can be used to build predictive mathematical models of embryogenesis. Current modelling approaches are, however, limited by lack of methods to automatically infer the regulatory networks and the parameter values from the image-based information. Here we make a ...
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In this work we address the task of adapting the model representation of a given image, in the context of a second, target image model. We present the BlobEMD framework, in which the images are represented as sets of blobs and optimal correspondences are found between the representations of the images and are used to adapt the representation of the source image to that of the target image. The ...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2015
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbv093